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asifahamed11 / TF-DFE

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Evidence-aware somatic variant pathogenicity classifier using topology (TDA), fractal (FCGR) features, and dynamic ensemble selection (KNORA). MCC=0.8702, AUROC=0.9666 on 207K variants from dbNSFP v5.3a.

python machine-learning bioinformatics somatic-variants cancer-genomics ensemble-learning pathogenicity persistent-homology topological-data-analysis knora dbnsfp shap fcgr variant-classification dynamic-ensemble-selection
  • Updated Mar 9, 2026
  • Python

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