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---
layout: default
title: Schatzlab - Welcome
---
<table class="intro">
<tr> <td width="544" valign="top">
<span class="contenthead">Welcome</span><br><hr>
Our main research interest is in understanding the structure and function of genomes, especially those of medical or
agricultural importance. The core strength of our research is in developing novel algorithms and computational systems
for large-scale biological sequence analysis, including leading algorithms for de novo genome assembly, variant detection,
and related –omics assays. Using these advances we have contributed to the de novo genome assemblies of dozens of species;
probed the sequence variations related to autism, cancer, and other human diseases; mapped the transcriptional and epigenetic
profiles of tomatoes, corn, and other important plant species; and explored the role of microbes in different environments.
In response to the deluge of biological sequence data we are now facing, we have also been at the forefront of distributed
and parallel computing in genomics, and have pioneered the use of cloud computing as an enabling platform to
address the big data challenges we are all facing.
<br><br>
Looking forward, we see ourselves at the intersection of biotechnology and algorithmics, developing systems for probing
the structure and function of genomes using the best technologies possible. Our expertise spans from low level computer
architecture, through sequencing, de novo assembly, variant identification, transcriptome & other -omics data
and up to machine learning approaches to build predictive models of diseases and treatment response. In addition to ongoing
projects in autism, cancer, and other human diseases, we also study agricultural systems to better understand the underlying
genotype to phenotype relations. Altogether, we intend to develop powerful new methods for analyzing large collections
of genomes to address questions of disease, development, and evolution. Among other recognition, for this work I was granted
an NSF CAREER award, a Sloan Foundation Fellowship, and was named a TIME100 recipient in 2022.
<br><br>
<span class="contenthead">Recent News</span><hr>
<table class="intro" width=100%>
<tr>
<td valign=top width=10>»</td>
<td valign=top><a href="https://www.nature.com/articles/s41467-026-71755-8">Assembling unmapped reads reveals hidden variation in South Asian genomes </a><br>April 10, 2026<td> </tr>
<tr><td height=8 colspan=2></td></tr>
<tr>
<td valign=top width=10>»</td>
<td valign=top><a href="https://www.biorxiv.org/content/10.64898/2026.03.06.710148v1">Perseus: Lineage-Aware Refinement of Kraken2 Taxonomic Classification for Long Read Metagenomes</a><br>March 9, 2026<td> </tr>
<tr><td height=8 colspan=2></td></tr>
<tr>
<td valign=top width=10>»</td>
<td valign=top><a href="https://www.biorxiv.org/content/10.64898/2026.02.20.707063v1">A neofunctionalized flowering antagonist created an evolutionary contingency that channeled Solanaceae adaptation</a><br>Feb 21, 2026<td> </tr>
<tr><td height=8 colspan=2></td></tr>
<tr>
<td valign=top width=10>»</td>
<td valign=top><a href="https://www.biorxiv.org/content/10.64898/2026.01.27.702063v1">AniAnn's: alignment-free annotation of tandem repeat arrays using fast average nucleotide identity estimates</a><br>Jan 28, 2026<td> </tr>
<tr><td height=8 colspan=2></td></tr>
<tr>
<td valign=top width=10>»</td>
<td valign=top><a href="https://www.medrxiv.org/content/10.64898/2026.01.24.25343227v1">Behavioral Assessment Reliability in Clinical Phenotyping and Biomarker Research for Autism</a><br>Jan 26, 2026<td> </tr>
<tr><td height=8 colspan=2></td></tr>
<tr><td colspan=2 align=right>(<a href="/news/">past news</a>)</td></tr>
</table>
<br>
<span class="contenthead">Upcoming Events</span><br> <hr>
<table class="intro" width=100%>
<tr><td height=8 colspan=2><b>~~ 2026 ~~<b><br><br></td></tr>
<tr>
<td valign=top width=10>»</td>
<td valign=top> <a href="https://meetings.cshl.edu/meetings.aspx?meet=GENOME&year=26">Biology of Genomes</a><br>
CSHL, NY. May 2026</td>
</tr> <tr><td height=8 colspan=2></td></tr>
<tr>
<td valign=top width=10>»</td>
<td valign=top> <a href="https://galaxyproject.org/gcc/">Galaxy Community Conference</a><br>
Summer 2026</td>
</tr> <tr><td height=8 colspan=2></td></tr>
<tr>
<td valign=top width=10>»</td>
<td valign=top> <a href="https://anvilproject.org/">AnVIL Community Conference</a><br>
Fall 2026</td>
</tr> <tr><td height=8 colspan=2></td></tr>
<tr>
<td valign=top width=10>»</td>
<td valign=top> <a href="https://www.ashg.org/meetings/">American Society of Human Genetics</a><br>
Fall 2026</td>
</tr> <tr><td height=8 colspan=2></td></tr>
<tr>
<td valign=top width=10>»</td>
<td valign=top> <a href="https://meetings.cshl.edu/meetings.aspx?meet=DATA&year=26">Biological Data Science</a><br>
Fall 2026</td>
</tr> <tr><td height=8 colspan=2></td></tr>
<tr><td height=8 colspan=2><b>~~ 2027 ~~<b><br><br></td></tr>
<tr>
<td valign=top width=10>»</td>
<td valign=top> <a href="https://www.intlpag.org">Plant and Animal Genomes Conference (PAG)</a><br>
San Diego, CA. Jan 2027</td>
</tr> <tr><td height=8 colspan=2></td></tr>
<tr>
<td valign=top width=10>»</td>
<td valign=top> <a href="http://www.agbt.org">Advances in Genome Biology and Technology (AGBT)</a><br>
Orlando, FL. Feb 2026</td>
</tr> <tr><td height=8 colspan=2></td></tr>
<tr><td colspan=2 align=right>(<a href="/presentations/">presentation archive</a>)</td></tr>
</table>
</td>
<td width="230" valign="top" align=center>
<br>
<img src="/images/2015-Schatz.JPG" width="198" height="300" border="2">
<br><br>
<table class="intro"> <tr> <td align="left">
<b>Michael Schatz</b><br>
<br>
Bloomberg Distinguished<br>
Professor of Computer Science<br>
and Biology<br>
<br>
CS office and Mailing address:<br>
Johns Hopkins University<br>
Department of Computer Science<br>
3400 N Charles St<br>
Malone Hall 323<br>
Baltimore, MD 21218<br>
<br>
Department of Biology:<br>
UTL 391 (office) <br>
UTL 398 (lab and conference room) <br>
<br>
Cell: (703) 966-1987 <br>
E-mail: mschatz <at> cs.jhu.edu <br>
Twitter: <a href="http://twitter.com/mike_schatz">@mike_schatz</a> <br>
LinkedIn: <a href="https://www.linkedin.com/in/mschatz/">mschatz</a> <br>
BlueSky: <a href="https://bsky.app/profile/mikeschatz.bsky.social">mikeschatz.bsky.social</a> <br>
ORCID: <a href="https://orcid.org/0000-0002-4118-4446">0000-0002-4118-4446</a> <br>
</td> </tr> </table>
</td>
</tr>
</table>