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README.md

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RF-Score-VS is a novel Random Forest-based scoring function for Virtual Screening which predicts binding affinity.
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Its descriptors are based on RF-Score developed by Pedro Ballester et. al.
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Presented binary implements RF-Score-VS v2, meaning, it counts atoms of certain types within a 12A radius, divided into 2A bins.
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Further information about reported performance in various scenarios and validation across datasets, see the publication in **[article submitted]**
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Further information about reported performance in various scenarios and validation across datasets, see the [publication](https://dx.doi.org/10.1038/srep46710).
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## Supported platforms
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* [Linux 64-bit](http://wojcikowski.pl/travis/rf-score-vs_v1.0_linux_2.7.zip)
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* [Windows 64-bit](http://wojcikowski.pl/travis/rf-score-vs_v1.0_win_2.7.zip)
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* [MacOS 64-bit](http://wojcikowski.pl/travis/rf-score-vs_v1.0_macos_2.7.zip)
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* [MacOS 64-bit](http://wojcikowski.pl/travis/rf-score-vs_v1.0_osx_2.7.zip)
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## Supported multi-molecular formats:
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## References:
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* Wójcikowski M, Ballester P.J, Siedlecki P. Performance of machine-learning scoring functions in structure-based virtual screening. article submitted
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* Wójcikowski M, Ballester PJ, Siedlecki P. Performance of machine-learning scoring functions in structure-based virtual screening. Sci Rep. Nature Publishing Group; 2017;7: 46710. [doi:10.1038/srep46710](https://dx.doi.org/10.1038/srep46710)
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* Wójcikowski M, Zielenkiewicz P, Siedlecki P. Open Drug Discovery Toolkit (ODDT): a new open-source player in the drug discovery field. J Cheminform. 2015;7: 5317. [doi:10.1186/s13321-015-0078-2](https://dx.doi.org/10.1186/s13321-015-0078-2)
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