diff --git a/dev-packages/cloudflare-integration-tests/suites/public-api/startSpan-streamed/test.ts b/dev-packages/cloudflare-integration-tests/suites/public-api/startSpan-streamed/test.ts
index d9c18431202b..b59fd3d6991c 100644
--- a/dev-packages/cloudflare-integration-tests/suites/public-api/startSpan-streamed/test.ts
+++ b/dev-packages/cloudflare-integration-tests/suites/public-api/startSpan-streamed/test.ts
@@ -243,6 +243,14 @@ it('sends a streamed span envelope with correct spans for a manually started spa
             type: 'integer',
             value: 200,
           },
+          'cloud.provider': {
+            type: 'string',
+            value: 'cloudflare',
+          },
+          'culture.timezone': {
+            type: 'string',
+            value: expect.any(String),
+          },
           'network.protocol.name': {
             type: 'string',
             value: 'HTTP/1.1',
diff --git a/dev-packages/node-integration-tests/suites/context-streamed/scope-contexts/scenario.ts b/dev-packages/node-integration-tests/suites/context-streamed/scope-contexts/scenario.ts
new file mode 100644
index 000000000000..f29857444e4d
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/context-streamed/scope-contexts/scenario.ts
@@ -0,0 +1,22 @@
+import * as Sentry from '@sentry/node';
+import { loggingTransport } from '@sentry-internal/node-integration-tests';
+
+Sentry.init({
+  dsn: 'https://public@dsn.ingest.sentry.io/1337',
+  tracesSampleRate: 1.0,
+  traceLifecycle: 'stream',
+  transport: loggingTransport,
+});
+
+Sentry.withIsolationScope(isolationScope => {
+  isolationScope.setContext('response', { status_code: 200 });
+  isolationScope.setContext('cloud_resource', { 'cloud.provider': 'aws', 'cloud.region': 'us-east-1' });
+  isolationScope.setContext('profile', { profile_id: 'abc123' });
+  isolationScope.setContext('react', { version: '18.2.0' });
+
+  Sentry.startSpan({ name: 'test-span' }, () => {
+    // noop
+  });
+});
+
+void Sentry.flush();
diff --git a/dev-packages/node-integration-tests/suites/context-streamed/scope-contexts/test.ts b/dev-packages/node-integration-tests/suites/context-streamed/scope-contexts/test.ts
new file mode 100644
index 000000000000..c344fcf5052f
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/context-streamed/scope-contexts/test.ts
@@ -0,0 +1,33 @@
+import { afterAll, expect, test } from 'vitest';
+import { cleanupChildProcesses, createRunner } from '../../../utils/runner';
+
+afterAll(() => {
+  cleanupChildProcesses();
+});
+
+test('scope contexts are converted to segment span attributes in span streaming', async () => {
+  await createRunner(__dirname, 'scenario.ts')
+    .expect({
+      span: container => {
+        const segmentSpan = container.items.find(s => !!s.is_segment);
+        expect(segmentSpan).toBeDefined();
+
+        const attrs = segmentSpan!.attributes!;
+
+        // response context -> http.response.* attributes
+        expect(attrs['http.response.status_code']).toEqual({ type: 'integer', value: 200 });
+
+        // cloud_resource context (dot-notation passthrough)
+        expect(attrs['cloud.provider']).toEqual({ type: 'string', value: 'aws' });
+        expect(attrs['cloud.region']).toEqual({ type: 'string', value: 'us-east-1' });
+
+        // profile context
+        expect(attrs['sentry.profile_id']).toEqual({ type: 'string', value: 'abc123' });
+
+        // framework version context
+        expect(attrs['react.version']).toEqual({ type: 'string', value: '18.2.0' });
+      },
+    })
+    .start()
+    .completed();
+});
diff --git a/packages/core/src/tracing/spans/captureSpan.ts b/packages/core/src/tracing/spans/captureSpan.ts
index bed3f1790740..2bb86f8cb0d0 100644
--- a/packages/core/src/tracing/spans/captureSpan.ts
+++ b/packages/core/src/tracing/spans/captureSpan.ts
@@ -27,6 +27,7 @@ import {
 } from '../../utils/spanUtils';
 import { getCapturedScopesOnSpan } from '../utils';
 import { isStreamedBeforeSendSpanCallback } from './beforeSendSpan';
+import { scopeContextsToSpanAttributes } from './scopeContextAttributes';
 
 export type SerializedStreamedSpanWithSegmentSpan = SerializedStreamedSpan & {
   _segmentSpan: Span;
@@ -96,9 +97,9 @@ export function captureSpan(span: Span, client: Client): SerializedStreamedSpanW
   };
 }
 
-function applyScopeToSegmentSpan(_segmentSpanJSON: StreamedSpanJSON, _scopeData: ScopeData): void {
-  // TODO: Apply contexts data from auto instrumentation to segment span
-  // This will follow in a separate PR
+function applyScopeToSegmentSpan(segmentSpanJSON: StreamedSpanJSON, scopeData: ScopeData): void {
+  const contextAttributes = scopeContextsToSpanAttributes(scopeData.contexts);
+  safeSetSpanJSONAttributes(segmentSpanJSON, contextAttributes);
 }
 
 /**
diff --git a/packages/core/src/tracing/spans/scopeContextAttributes.ts b/packages/core/src/tracing/spans/scopeContextAttributes.ts
new file mode 100644
index 000000000000..17f58f53fdde
--- /dev/null
+++ b/packages/core/src/tracing/spans/scopeContextAttributes.ts
@@ -0,0 +1,75 @@
+import type { Contexts } from '../../types-hoist/context';
+
+/**
+ * Convert known scope contexts set by SDK integrations to span attributes.
+ * Only maps context keys that are relevant to browser SDKs.
+ * Server-only contexts (aws, gcp, missing_instrumentation, trpc) are handled
+ * by processSegmentSpan hooks in their respective packages.
+ */
+export function scopeContextsToSpanAttributes(contexts: Contexts): Record<string, unknown> {
+  const attrs: Record<string, unknown> = {};
+
+  const { response, profile, cloud_resource, culture, state } = contexts;
+
+  if (response) {
+    if (response.status_code != null) {
+      attrs['http.response.status_code'] = response.status_code;
+    }
+    if (response.body_size != null) {
+      attrs['http.response.body.size'] = response.body_size;
+    }
+  }
+
+  if (profile) {
+    if (profile.profile_id) {
+      attrs['sentry.profile_id'] = profile.profile_id;
+    }
+    if (profile.profiler_id) {
+      attrs['sentry.profiler_id'] = profile.profiler_id;
+    }
+    if (profile.start_timestamp != null) {
+      attrs['profile.start_timestamp'] = profile.start_timestamp;
+    }
+  }
+
+  // CloudResourceContext keys are already in dot-notation (OTel resource conventions)
+  if (cloud_resource) {
+    for (const [key, value] of Object.entries(cloud_resource)) {
+      if (value != null) {
+        attrs[key] = value;
+      }
+    }
+  }
+
+  if (culture) {
+    if (culture.locale) {
+      attrs['culture.locale'] = culture.locale;
+    }
+    if (culture.timezone) {
+      attrs['culture.timezone'] = culture.timezone;
+    }
+  }
+
+  if (state?.state && typeof state.state.type === 'string') {
+    attrs['state.type'] = state.state.type;
+  }
+
+  // Framework version contexts
+  const angular = contexts['angular'];
+  if (angular) {
+    const version = angular['version'];
+    if (typeof version === 'string' || typeof version === 'number') {
+      attrs['angular.version'] = version;
+    }
+  }
+
+  const react = contexts['react'];
+  if (react) {
+    const version = react['version'];
+    if (typeof version === 'string' || typeof version === 'number') {
+      attrs['react.version'] = version;
+    }
+  }
+
+  return attrs;
+}
diff --git a/packages/core/test/lib/tracing/spans/captureSpan.test.ts b/packages/core/test/lib/tracing/spans/captureSpan.test.ts
index 186f7f23a536..e1d4861a110f 100644
--- a/packages/core/test/lib/tracing/spans/captureSpan.test.ts
+++ b/packages/core/test/lib/tracing/spans/captureSpan.test.ts
@@ -1,5 +1,5 @@
 import { describe, expect, it, vi } from 'vitest';
-import type { StreamedSpanJSON } from '../../../../src';
+import type { Contexts, StreamedSpanJSON } from '../../../../src';
 import {
   captureSpan,
   SEMANTIC_ATTRIBUTE_SENTRY_ENVIRONMENT,
@@ -22,6 +22,7 @@ import {
   withStreamedSpan,
 } from '../../../../src';
 import { inferSpanDataFromOtelAttributes, safeSetSpanJSONAttributes } from '../../../../src/tracing/spans/captureSpan';
+import { scopeContextsToSpanAttributes } from '../../../../src/tracing/spans/scopeContextAttributes';
 import { getDefaultTestClientOptions, TestClient } from '../../../mocks/client';
 
 describe('captureSpan', () => {
@@ -638,3 +639,209 @@ describe('inferSpanDataFromOtelAttributes', () => {
     expect(spanJSON.name).toBe('test');
   });
 });
+
+describe('scopeContextsToSpanAttributes', () => {
+  it('returns empty object for empty contexts', () => {
+    expect(scopeContextsToSpanAttributes({})).toEqual({});
+  });
+
+  it('ignores unknown context names', () => {
+    const contexts: Contexts = { my_custom_context: { foo: 'bar' } };
+    expect(scopeContextsToSpanAttributes(contexts)).toEqual({});
+  });
+
+  describe('response context', () => {
+    it('maps status_code and body_size', () => {
+      const contexts: Contexts = { response: { status_code: 200, body_size: 1024 } };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+        'http.response.status_code': 200,
+        'http.response.body.size': 1024,
+      });
+    });
+
+    it('omits missing fields', () => {
+      const contexts: Contexts = { response: { status_code: 404 } };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+        'http.response.status_code': 404,
+      });
+    });
+  });
+
+  describe('profile context', () => {
+    it('maps profile_id to sentry.profile_id', () => {
+      const contexts: Contexts = { profile: { profile_id: 'abc123' } };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+        'sentry.profile_id': 'abc123',
+      });
+    });
+
+    it('maps profiler_id to sentry.profiler_id', () => {
+      const contexts: Contexts = { profile: { profile_id: '', profiler_id: 'prof-1' } };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+        'sentry.profiler_id': 'prof-1',
+      });
+    });
+
+    it('maps start_timestamp', () => {
+      const contexts: Contexts = { profile: { profile_id: 'abc', start_timestamp: 1234567890 } };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+        'sentry.profile_id': 'abc',
+        'profile.start_timestamp': 1234567890,
+      });
+    });
+
+    it('produces no attributes for empty profile context', () => {
+      const contexts: Contexts = { profile: { profile_id: '' } };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({});
+    });
+  });
+
+  describe('cloud_resource context', () => {
+    it('passes through dot-notation keys', () => {
+      const contexts: Contexts = {
+        cloud_resource: { 'cloud.provider': 'cloudflare', 'cloud.region': 'us-east-1' },
+      };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+        'cloud.provider': 'cloudflare',
+        'cloud.region': 'us-east-1',
+      });
+    });
+
+    it('filters out null values', () => {
+      const contexts: Contexts = {
+        cloud_resource: { 'cloud.provider': 'aws', 'cloud.region': undefined },
+      };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+        'cloud.provider': 'aws',
+      });
+    });
+  });
+
+  describe('culture context', () => {
+    it('maps locale and timezone', () => {
+      const contexts: Contexts = { culture: { locale: 'en-US', timezone: 'America/New_York' } };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+        'culture.locale': 'en-US',
+        'culture.timezone': 'America/New_York',
+      });
+    });
+
+    it('omits missing fields', () => {
+      const contexts: Contexts = { culture: { timezone: 'UTC' } };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+        'culture.timezone': 'UTC',
+      });
+    });
+  });
+
+  describe('state context', () => {
+    it('maps state.type only', () => {
+      const contexts: Contexts = {
+        state: { state: { type: 'redux', value: { counter: 42, user: { name: 'test' } } } },
+      };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+        'state.type': 'redux',
+      });
+    });
+
+    it('does not map state.value', () => {
+      const contexts: Contexts = {
+        state: { state: { type: 'pinia', value: { items: [1, 2, 3] } } },
+      };
+      const attrs = scopeContextsToSpanAttributes(contexts);
+      expect(attrs).not.toHaveProperty('state.value');
+      expect(attrs).not.toHaveProperty('state.state.value');
+    });
+
+    it('handles missing state.state gracefully', () => {
+      const contexts: Contexts = { state: {} as any };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({});
+    });
+  });
+
+  describe('framework version contexts', () => {
+    it('maps angular.version', () => {
+      const contexts: Contexts = { angular: { version: 17 } };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+        'angular.version': 17,
+      });
+    });
+
+    it('maps react.version', () => {
+      const contexts: Contexts = { react: { version: '18.2.0' } };
+      expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+        'react.version': '18.2.0',
+      });
+    });
+  });
+
+  it('maps multiple contexts at once', () => {
+    const contexts: Contexts = {
+      response: { status_code: 200 },
+      culture: { timezone: 'UTC' },
+      react: { version: '18.2.0' },
+    };
+    expect(scopeContextsToSpanAttributes(contexts)).toEqual({
+      'http.response.status_code': 200,
+      'culture.timezone': 'UTC',
+      'react.version': '18.2.0',
+    });
+  });
+});
+
+describe('applyScopeToSegmentSpan integration', () => {
+  it('applies scope contexts to segment span attributes', () => {
+    const client = new TestClient(
+      getDefaultTestClientOptions({
+        dsn: 'https://dsn@ingest.f00.f00/1',
+        tracesSampleRate: 1,
+        release: '1.0.0',
+        environment: 'production',
+      }),
+    );
+
+    const span = withScope(scope => {
+      scope.setClient(client);
+      scope.setContext('response', { status_code: 201 });
+      scope.setContext('culture', { timezone: 'Europe/Berlin' });
+
+      const span = startInactiveSpan({ name: 'test-span' });
+      span.end();
+      return span;
+    });
+
+    const serialized = captureSpan(span, client);
+
+    expect(serialized.attributes).toEqual(
+      expect.objectContaining({
+        'http.response.status_code': { type: 'integer', value: 201 },
+        'culture.timezone': { type: 'string', value: 'Europe/Berlin' },
+      }),
+    );
+  });
+
+  it('does not apply scope contexts to child spans', () => {
+    const client = new TestClient(
+      getDefaultTestClientOptions({
+        dsn: 'https://dsn@ingest.f00.f00/1',
+        tracesSampleRate: 1,
+        release: '1.0.0',
+        environment: 'production',
+      }),
+    );
+
+    const serializedChild = withScope(scope => {
+      scope.setClient(client);
+      scope.setContext('response', { status_code: 200 });
+
+      return startSpan({ name: 'segment' }, () => {
+        const childSpan = startInactiveSpan({ name: 'child' });
+        childSpan.end();
+        return captureSpan(childSpan, client);
+      });
+    });
+
+    expect(serializedChild?.is_segment).toBe(false);
+    expect(serializedChild?.attributes).not.toHaveProperty('http.response.status_code');
+  });
+});