diff --git a/api/draft_registrations/permissions.py b/api/draft_registrations/permissions.py
index 5232ee9d546..fb6829aafa0 100644
--- a/api/draft_registrations/permissions.py
+++ b/api/draft_registrations/permissions.py
@@ -1,11 +1,13 @@
 from rest_framework import permissions
 
+from api.base.exceptions import Conflict
 from api.base.utils import get_user_auth, assert_resource_type
 from osf.models import (
     DraftRegistration,
     AbstractNode,
     DraftRegistrationContributor,
     OSFUser,
+    RegistrationProvider,
 )
 from api.nodes.permissions import ContributorDetailPermissions
 from osf.utils.permissions import WRITE, ADMIN
@@ -90,3 +92,32 @@ def has_object_permission(self, request, view, obj):
             elif isinstance(obj, AbstractNode):
                 return obj.has_permission(auth.user, WRITE)
         return False
+
+
+class CanSubmitDraftRegistrationToProvider(permissions.BasePermission):
+    """
+    Prevent creating draft registrations for providers that are closed to submissions.
+    """
+
+    def has_permission(self, request, view):
+        if request.method != 'POST':
+            return True
+
+        provider_id = request.data.get('provider')
+
+        if not provider_id:
+            try:
+                provider = RegistrationProvider.get_default()
+            except RegistrationProvider.DoesNotExist:
+                return True
+        else:
+            try:
+                provider = RegistrationProvider.objects.get(_id=provider_id)
+            except RegistrationProvider.DoesNotExist:
+                # Let existing validation handle bad provider ids.
+                return True
+
+        if not provider.allow_submissions:
+            raise Conflict(f"Registry {provider.name} is closed for new submissions. Please start a new registration with a different registry.")
+
+        return True
diff --git a/api/draft_registrations/views.py b/api/draft_registrations/views.py
index 30c583dd94a..88a266c9ab6 100644
--- a/api/draft_registrations/views.py
+++ b/api/draft_registrations/views.py
@@ -8,6 +8,7 @@
     DraftContributorDetailPermissions,
     DraftRegistrationPermission,
     IsAdminContributor,
+    CanSubmitDraftRegistrationToProvider,
 )
 from api.draft_registrations.serializers import (
     DraftRegistrationSerializer,
@@ -53,6 +54,7 @@ class DraftRegistrationList(NodeDraftRegistrationsList):
         drf_permissions.IsAuthenticatedOrReadOnly,
         base_permissions.TokenHasScope,
         DraftRegistrationPermission,
+        CanSubmitDraftRegistrationToProvider,
     )
 
     view_category = 'draft_registrations'
diff --git a/api/nodes/views.py b/api/nodes/views.py
index 69c7fa7d25e..51648d365cd 100644
--- a/api/nodes/views.py
+++ b/api/nodes/views.py
@@ -74,7 +74,10 @@
     NodeCommentSerializer,
 )
 from api.draft_registrations.serializers import DraftRegistrationSerializer, DraftRegistrationDetailSerializer
-from api.draft_registrations.permissions import DraftRegistrationPermission
+from api.draft_registrations.permissions import (
+    DraftRegistrationPermission,
+    CanSubmitDraftRegistrationToProvider,
+)
 from api.files.serializers import FileSerializer, OsfStorageFileSerializer
 from api.files import annotations as file_annotations
 from api.identifiers.serializers import NodeIdentifierSerializer
@@ -671,6 +674,7 @@ class NodeDraftRegistrationsList(JSONAPIBaseView, generics.ListCreateAPIView, No
         DraftRegistrationPermission,
         drf_permissions.IsAuthenticatedOrReadOnly,
         base_permissions.TokenHasScope,
+        CanSubmitDraftRegistrationToProvider,
     )
 
     parser_classes = (JSONAPIMultipleRelationshipsParser, JSONAPIMultipleRelationshipsParserForRegularJSON)
diff --git a/api_tests/draft_registrations/views/test_draft_registration_list.py b/api_tests/draft_registrations/views/test_draft_registration_list.py
index 4aed087605a..c2c0cce084c 100644
--- a/api_tests/draft_registrations/views/test_draft_registration_list.py
+++ b/api_tests/draft_registrations/views/test_draft_registration_list.py
@@ -399,6 +399,19 @@ def test_affiliated_institutions_are_copied_from_user(self, app, user, url_draft
         draft_registration = DraftRegistration.load(res.json['data']['id'])
         assert list(draft_registration.affiliated_institutions.all()) == list(user.get_affiliated_institutions())
 
+    def test_cannot_create_draft_when_provider_disallows_submissions(
+            self, app, user, provider, payload, url_draft_registrations):
+        provider.allow_submissions = False
+        provider.save()
+
+        res = app.post_json_api(
+            url_draft_registrations,
+            payload,
+            auth=user.auth,
+            expect_errors=True,
+        )
+        assert res.status_code == 409
+
 
 class TestDraftRegistrationCreateWithoutNode(AbstractDraftRegistrationTestCase):
     @pytest.fixture()
@@ -451,6 +464,19 @@ def test_create_draft_with_provider(
         draft = DraftRegistration.load(data['id'])
         assert draft.provider == non_default_provider
 
+    def test_cannot_create_draft_when_provider_disallows_submissions(
+            self, app, user, url_draft_registrations, non_default_provider, payload_with_non_default_provider):
+        non_default_provider.allow_submissions = False
+        non_default_provider.save()
+
+        res = app.post_json_api(
+            url_draft_registrations,
+            payload_with_non_default_provider,
+            auth=user.auth,
+            expect_errors=True,
+        )
+        assert res.status_code == 409
+
     def test_write_contrib(self, app, user, project_public, payload, url_draft_registrations, user_write_contrib):
         """(no node supplied, so any logged in user can create)
         """