{
"orcid": "0000-0003-4866-9953",
"references": [
{
"type": "doi",
"id": "10.1021/jacs.5c13143",
"title": "Logical Exploration of Cinnamoyl-Containing Nonribosomal Peptides via Metabologenomic Targeting and Regulator Overexpression",
"url": "https://doi.org/10.1021/jacs.5c13143"
}
],
"protein_name": "XYI78305.1",
"protein_sequence": "MTESKPRLEGILPLSPLQQGLLFHAQYDVQGPDAYTMQFVLDIEGGLDTGALHSACAAVMRRHAVLRAAFRHRKNGEPVQLIPYEVAPDWTHRDLTGRPAAESAAEAERIAAEDRARRFDLARPPLIRFTLVSLGDDRHQFLVTAHHILLDGWSRALLIGELFQLYGLCRTGADETALPRVAPYRDYLAWVAAQDRPAAEEAWRRVLDGVEEPTLLAAPDPSREPLAPARTRVELPAAETAALTRWARERGVTVNTVVQAAWAIVLGRLTGRDDVLFGGTVSGRPPQLPGVESMVGLFINTLPVRVRLDPAETVGALLERLQDQQAALMDCQYLGLADLQRLTPVGGELFDTLLVFENYPVDTEGLRRSAGGLGVVDGRSHEGTHYPLGLLVHAGDTLAVELSHRPDVLDRAGATAVGDSLLRLLAAFTGAESTPVGRLDLLTAADRARVLTEWNDTARESADTTLPELFRRTADRYPGAVAVQDGATTLTYRELDARANRLARLLAARGAGPEQTVALALPRSAELIVALWAVLKSGAAYLPVDTGYPADRIAHMLGDARPVLVLAHHATVPVLPAGDRTPRLLLDDPGTAADLAALPDSGLTDADRTAPLTPPAPAYVIYTSGSTGWPKGVTMPGSALANLVGWHEEELPGGPGVRTAQFTAVSFDVSAQEILSATLSGRTLVIPDEDTRRDPAAFVRWLDEQRVDEVYAPNLVIDALCEEAIGQGLELPALRHLAQAGEALLPTKRIRDFHHGTGRVLHNHYGPTETHVVTATTLPADPGAWPARPTIGRPIRNTRAYVLDSALRPVQPGVPGELYLAGAGLARGYLGRPDLTAERFTADPYGPAGGRMYRTGDVVRWTGGGELDYLGRSDHQVKIRGFRIELGEIEAALTAHPAVAQAAVLAREDRPGLRTIAAYLVPAAGRTVPTAAELRAHLDGTLPDYMVPSAFVPLAELPLTPNRKLDRRALPVPDGAAAEGRAPRNAREARLCRLFAAVLGVERVSVDDGFFDLGGHSLLATRLVSQVRTAFGVELAVRALFEAPTVAALADRIAAAGRARRALTAGPRPEEVPLSPAQRRLWFLGRFEDAGGNYHLPMAVRLSGELRTDALRAALDDLLTRHESLRTVFPETDGRPRQHVLDPAKAAVELPVTGIAEEDLDRALAAAAGEEFDLAAEPPLRARLFALGAGEHVLLLVVHHIAADGWSMAPLARDLGEAYRARCAGRAPGWEPLPVQYADYTLWQRDVLGDESDPESELSRQIGFWRTTLAGLPEELALPVDRPRPPKTSHRGDTVALMIPADTHRRLAALAREQRASVFMVARAALAALLHRLGAGEDIPVGTPVAGRTDQALDELVGFFVNTLVLRTDVSGDPTFRELVERVRETDLAAYAHQDVPFERLVEILNPERSLARHPLFQVMLSFQNNTEATLDLAGVGAAAQPVGLRTATFDLSVVLAERFTGDGAPDGIDGGIEYATDLFDRETAQELADRLVRLVAELVSEPDRPLSAARMLTEAERHRVLAEWNDTAREHPADTLPGLFERQAARTPEATALVFRDVRLSYAELNTRANRLARRLLADGVRPEQAVAVVLPRSAEQIVALLAVMKAGAVHLPVDAGYPADRVAHMLDDARPVAVLADAAELRAVGSDQAWSGEDLTADERGAAPRPDNAAYVIYTSGSTGRPKGVTVQHRSVANLFHDHFGRLYGPVIAAAGGRRLRASLCASLSFDAAVDPLLWMVAGHELHLLDDETRQDAAALCAYAQRVGGLDYVDTTPGHFQQLHELGLTEGPFRPLIVALGGEAMGETLRADLAAVEGLAAYNLYGPTETTVDALGQRIDDSDRVRVGRPLDNYRAYVLDAALRPVVPGVAGELYLAGAGLARGYLGRPDLTAERFTADPYGAPGARMYRTGDLARWTRDGRIDCLGRVDDQVKVRGFRVELGEIEAALESHEDISQAAVLVREDRPGVRELVAYAVPAAGRPVPAPDELRRRLGDGLPDYMVPAAYVTLDRLPVTVNGKLDRKALPAPGPRTGADGRPPRTAAEKALCDIFAEVLGVERVSVDDGFFDLGGHSLLATRVVSRVRSRLGVELAVRTLFEAPTAAALAERVGEAGNARTALTARRRPEEIPLSPGQRRLWFLNRVQGSDATYNMPLAVRLTGPLDASALEAALGDVVARHESLRTIFPDAGGRPRQLILPAEEARPVLATAEFDAGALAAETARGFDLSVELPVRAGLFGVSPVEHVLLVVVHHIAGDGWSMGPLARDLGRAYAARCAGGAPGWEPLPVQYADYTLWQREVLGEEGDPGSELSRQVEYWRGALADLPEELALPVDRPRPAGMSHRGGTVAFRVPQEARERLVALAGETGTSLFMVVQAALVTLLHRLGAGEDIPVGTVIAGRTDEALDELVGFFVNTLVLRTDVSGDPTFRELLERVRETDLAAYANQDVPFERLVEVLNPERSMARHPLFQVMFAFQNTGEATLDLDGLHIAPEAVGFDAAKFDLSFTLAEAGSGLDGSVEFAVDLFDRVSVEVLAGRLVSVLEAVAADPGVRVGAVEVLSAGERSRILGSWAGSACAVEAVTFHGLFEAAVDAGPDAPAVVGGGFELSYAQVEARANRLAHWLIGRGVGVEDVVALVLPRSVDIVVAELAVLKAGAAYLPVDPEYPDERIAFMLEDARPVLVLRELPELGEGLAESRPGVAVSPRSAAYVIYTSGSTGRPKGVVVSHAGLASLAADERFAVDSQSRVLQFASPSFDASVFELTMAFAAGATLVVPPPGPLAGEPLAVLLAEQGVTHATLPPVVLAAMGDAGLPAGMSLVTAGEACSAELVERWSAGRRMVNAYGPTESTVCATMSGPLRAGTGAPSIGRPITNTRVYVLDAALRPVVPGVAGELYLAGAGLARGYLGRPGLTAERFTADPFGAPGARMYRTGDLARWSADGELDYLGRADDQVKVRGFRIELGEIESVVSRFDNAAQAVVVVREDQPGIKRLVAYVVPREGALDVAAIRAHVAATLPDYMVPSAFAELGELPVTVNGKLDRKALPVPGQDPDRSGRGPRSAQEEVLCGLFAEVLKADRVGIDDSFFELGGDSITSIQLVSRIRTVLGVKLSNRGIFETPTVARLAEKLGTGQDSDGFEVLLPLRTGGERLPLFCVHGAGGLSWPYSALLAHIGAEYPVYGLQARGLDGGGGIAVGVPEMAADYVEQIRSVQPSGPYHLMGWSFGALVAHEIATLLTEAGERVALLANLDQTPYDESWEDDDYVPPTERDILETLLDFVGYDLAEVREEPLDHLRAMELIRGRDSALGSLEERHITAFMKVGINNHALAARYQPRRFDGELLLFVSTADIDDPARKTAGSVAAWRPNVTGAITTHPIDAHHGHLLQPRPAAEIGRVVLERLTALSGAGPDQY",
"new_substrates": [],
"domains": [
{
"name": "XYI78305.1.A1",
"sequence": "FRRTADRYPGAVAVQDGATTLTYRELDARANRLARLLAARGAGPEQTVALALPRSAELIVALWAVLKSGAAYLPVDTGYPADRIAHMLGDARPVLVLAHHATVPVLPAGDRTPRLLLDDPGTAADLAALPDSGLTDADRTAPLTPPAPAYVIYTSGSTGWPKGVTMPGSALANLVGWHEEELPGGPGVRTAQFTAVSFDVSAQEILSATLSGRTLVIPDEDTRRDPAAFVRWLDEQRVDEVYAPNLVIDALCEEAIGQGLELPALRHLAQAGEALLPTKRIRDFHHGTGRVLHNHYGPTETHVVTATTLPADPGAWPARPTIGRPIRNTRAYVLDSALRPVQPGVPGELYLAGAGLARGYLGRPDLTAERFTADPYGPAGGRMYRTGDVVRWTGGGELDYLGRSDHQVKIRGFRIELGEIEAALTAHPAVAQAAVLAREDRPGLRTIAAYLVPAAGRTVPTAAELRAHLDGTLPDYMVPSAFVPLAELPLTPNRK",
"signature": "DVQYAAHVVK",
"extended_signature": "LWHTFDVSAQESYAAQAGEHNHYGPTETHVVTAT",
"substrates": [
"proline"
]
},
{
"name": "XYI78305.1.A2",
"sequence": "FERQAARTPEATALVFRDVRLSYAELNTRANRLARRLLADGVRPEQAVAVVLPRSAEQIVALLAVMKAGAVHLPVDAGYPADRVAHMLDDARPVAVLADAAELRAVGSDQAWSGEDLTADERGAAPRPDNAAYVIYTSGSTGRPKGVTVQHRSVANLFHDHFGRLYGPVIAAAGGRRLRASLCASLSFDAAVDPLLWMVAGHELHLLDDETRQDAAALCAYAQRVGGLDYVDTTPGHFQQLHELGLTEGPFRPLIVALGGEAMGETLRADLAAVEGLAAYNLYGPTETTVDALGQRIDDSDRVRVGRPLDNYRAYVLDAALRPVVPGVAGELYLAGAGLARGYLGRPDLTAERFTADPYGAPGARMYRTGDLARWTRDGRIDCLGRVDDQVKVRGFRVELGEIEAALESHEDISQAAVLVREDRPGVRELVAYAVPAAGRPVPAPDELRRRLGDGLPDYMVPAAYVTLDRLPVTVNGK",
"signature": "DADDAGLVDK",
"extended_signature": "LDHAFDAAVDPWDTALGGEYNLYGPTETTVDALG",
"substrates": [
"arginine"
]
},
{
"name": "XYI78305.1.A3",
"sequence": "FEAAVDAGPDAPAVVGGGFELSYAQVEARANRLAHWLIGRGVGVEDVVALVLPRSVDIVVAELAVLKAGAAYLPVDPEYPDERIAFMLEDARPVLVLRELPELGEGLAESRPGVAVSPRSAAYVIYTSGSTGRPKGVVVSHAGLASLAADERFAVDSQSRVLQFASPSFDASVFELTMAFAAGATLVVPPPGPLAGEPLAVLLAEQGVTHATLPPVVLAAMGDAGLPAGMSLVTAGEACSAELVERWSAGRRMVNAYGPTESTVCATMSGPLRAGTGAPSIGRPITNTRVYVLDAALRPVVPGVAGELYLAGAGLARGYLGRPGLTAERFTADPFGAPGARMYRTGDLARWSADGELDYLGRADDQVKVRGFRIELGEIESVVSRFDNAAQAVVVVREDQPGIKRLVAYVVPREGALDVAAIRAHVAATLPDYMVPSAFAELGELPVTVNGK",
"signature": "DAFTVAAVCK",
"extended_signature": "LDEAFDASVFEMTLVTAGEVNAYGPTESTVCATM",
"substrates": [
"phenylalanine"
]
}
]
}
{ "orcid": "0000-0003-4866-9953", "references": [ { "type": "doi", "id": "10.1021/jacs.5c13143", "title": "Logical Exploration of Cinnamoyl-Containing Nonribosomal Peptides via Metabologenomic Targeting and Regulator Overexpression", "url": "https://doi.org/10.1021/jacs.5c13143" } ], "protein_name": "XYI78305.1", "protein_sequence": "MTESKPRLEGILPLSPLQQGLLFHAQYDVQGPDAYTMQFVLDIEGGLDTGALHSACAAVMRRHAVLRAAFRHRKNGEPVQLIPYEVAPDWTHRDLTGRPAAESAAEAERIAAEDRARRFDLARPPLIRFTLVSLGDDRHQFLVTAHHILLDGWSRALLIGELFQLYGLCRTGADETALPRVAPYRDYLAWVAAQDRPAAEEAWRRVLDGVEEPTLLAAPDPSREPLAPARTRVELPAAETAALTRWARERGVTVNTVVQAAWAIVLGRLTGRDDVLFGGTVSGRPPQLPGVESMVGLFINTLPVRVRLDPAETVGALLERLQDQQAALMDCQYLGLADLQRLTPVGGELFDTLLVFENYPVDTEGLRRSAGGLGVVDGRSHEGTHYPLGLLVHAGDTLAVELSHRPDVLDRAGATAVGDSLLRLLAAFTGAESTPVGRLDLLTAADRARVLTEWNDTARESADTTLPELFRRTADRYPGAVAVQDGATTLTYRELDARANRLARLLAARGAGPEQTVALALPRSAELIVALWAVLKSGAAYLPVDTGYPADRIAHMLGDARPVLVLAHHATVPVLPAGDRTPRLLLDDPGTAADLAALPDSGLTDADRTAPLTPPAPAYVIYTSGSTGWPKGVTMPGSALANLVGWHEEELPGGPGVRTAQFTAVSFDVSAQEILSATLSGRTLVIPDEDTRRDPAAFVRWLDEQRVDEVYAPNLVIDALCEEAIGQGLELPALRHLAQAGEALLPTKRIRDFHHGTGRVLHNHYGPTETHVVTATTLPADPGAWPARPTIGRPIRNTRAYVLDSALRPVQPGVPGELYLAGAGLARGYLGRPDLTAERFTADPYGPAGGRMYRTGDVVRWTGGGELDYLGRSDHQVKIRGFRIELGEIEAALTAHPAVAQAAVLAREDRPGLRTIAAYLVPAAGRTVPTAAELRAHLDGTLPDYMVPSAFVPLAELPLTPNRKLDRRALPVPDGAAAEGRAPRNAREARLCRLFAAVLGVERVSVDDGFFDLGGHSLLATRLVSQVRTAFGVELAVRALFEAPTVAALADRIAAAGRARRALTAGPRPEEVPLSPAQRRLWFLGRFEDAGGNYHLPMAVRLSGELRTDALRAALDDLLTRHESLRTVFPETDGRPRQHVLDPAKAAVELPVTGIAEEDLDRALAAAAGEEFDLAAEPPLRARLFALGAGEHVLLLVVHHIAADGWSMAPLARDLGEAYRARCAGRAPGWEPLPVQYADYTLWQRDVLGDESDPESELSRQIGFWRTTLAGLPEELALPVDRPRPPKTSHRGDTVALMIPADTHRRLAALAREQRASVFMVARAALAALLHRLGAGEDIPVGTPVAGRTDQALDELVGFFVNTLVLRTDVSGDPTFRELVERVRETDLAAYAHQDVPFERLVEILNPERSLARHPLFQVMLSFQNNTEATLDLAGVGAAAQPVGLRTATFDLSVVLAERFTGDGAPDGIDGGIEYATDLFDRETAQELADRLVRLVAELVSEPDRPLSAARMLTEAERHRVLAEWNDTAREHPADTLPGLFERQAARTPEATALVFRDVRLSYAELNTRANRLARRLLADGVRPEQAVAVVLPRSAEQIVALLAVMKAGAVHLPVDAGYPADRVAHMLDDARPVAVLADAAELRAVGSDQAWSGEDLTADERGAAPRPDNAAYVIYTSGSTGRPKGVTVQHRSVANLFHDHFGRLYGPVIAAAGGRRLRASLCASLSFDAAVDPLLWMVAGHELHLLDDETRQDAAALCAYAQRVGGLDYVDTTPGHFQQLHELGLTEGPFRPLIVALGGEAMGETLRADLAAVEGLAAYNLYGPTETTVDALGQRIDDSDRVRVGRPLDNYRAYVLDAALRPVVPGVAGELYLAGAGLARGYLGRPDLTAERFTADPYGAPGARMYRTGDLARWTRDGRIDCLGRVDDQVKVRGFRVELGEIEAALESHEDISQAAVLVREDRPGVRELVAYAVPAAGRPVPAPDELRRRLGDGLPDYMVPAAYVTLDRLPVTVNGKLDRKALPAPGPRTGADGRPPRTAAEKALCDIFAEVLGVERVSVDDGFFDLGGHSLLATRVVSRVRSRLGVELAVRTLFEAPTAAALAERVGEAGNARTALTARRRPEEIPLSPGQRRLWFLNRVQGSDATYNMPLAVRLTGPLDASALEAALGDVVARHESLRTIFPDAGGRPRQLILPAEEARPVLATAEFDAGALAAETARGFDLSVELPVRAGLFGVSPVEHVLLVVVHHIAGDGWSMGPLARDLGRAYAARCAGGAPGWEPLPVQYADYTLWQREVLGEEGDPGSELSRQVEYWRGALADLPEELALPVDRPRPAGMSHRGGTVAFRVPQEARERLVALAGETGTSLFMVVQAALVTLLHRLGAGEDIPVGTVIAGRTDEALDELVGFFVNTLVLRTDVSGDPTFRELLERVRETDLAAYANQDVPFERLVEVLNPERSMARHPLFQVMFAFQNTGEATLDLDGLHIAPEAVGFDAAKFDLSFTLAEAGSGLDGSVEFAVDLFDRVSVEVLAGRLVSVLEAVAADPGVRVGAVEVLSAGERSRILGSWAGSACAVEAVTFHGLFEAAVDAGPDAPAVVGGGFELSYAQVEARANRLAHWLIGRGVGVEDVVALVLPRSVDIVVAELAVLKAGAAYLPVDPEYPDERIAFMLEDARPVLVLRELPELGEGLAESRPGVAVSPRSAAYVIYTSGSTGRPKGVVVSHAGLASLAADERFAVDSQSRVLQFASPSFDASVFELTMAFAAGATLVVPPPGPLAGEPLAVLLAEQGVTHATLPPVVLAAMGDAGLPAGMSLVTAGEACSAELVERWSAGRRMVNAYGPTESTVCATMSGPLRAGTGAPSIGRPITNTRVYVLDAALRPVVPGVAGELYLAGAGLARGYLGRPGLTAERFTADPFGAPGARMYRTGDLARWSADGELDYLGRADDQVKVRGFRIELGEIESVVSRFDNAAQAVVVVREDQPGIKRLVAYVVPREGALDVAAIRAHVAATLPDYMVPSAFAELGELPVTVNGKLDRKALPVPGQDPDRSGRGPRSAQEEVLCGLFAEVLKADRVGIDDSFFELGGDSITSIQLVSRIRTVLGVKLSNRGIFETPTVARLAEKLGTGQDSDGFEVLLPLRTGGERLPLFCVHGAGGLSWPYSALLAHIGAEYPVYGLQARGLDGGGGIAVGVPEMAADYVEQIRSVQPSGPYHLMGWSFGALVAHEIATLLTEAGERVALLANLDQTPYDESWEDDDYVPPTERDILETLLDFVGYDLAEVREEPLDHLRAMELIRGRDSALGSLEERHITAFMKVGINNHALAARYQPRRFDGELLLFVSTADIDDPARKTAGSVAAWRPNVTGAITTHPIDAHHGHLLQPRPAAEIGRVVLERLTALSGAGPDQY", "new_substrates": [], "domains": [ { "name": "XYI78305.1.A1", "sequence": "FRRTADRYPGAVAVQDGATTLTYRELDARANRLARLLAARGAGPEQTVALALPRSAELIVALWAVLKSGAAYLPVDTGYPADRIAHMLGDARPVLVLAHHATVPVLPAGDRTPRLLLDDPGTAADLAALPDSGLTDADRTAPLTPPAPAYVIYTSGSTGWPKGVTMPGSALANLVGWHEEELPGGPGVRTAQFTAVSFDVSAQEILSATLSGRTLVIPDEDTRRDPAAFVRWLDEQRVDEVYAPNLVIDALCEEAIGQGLELPALRHLAQAGEALLPTKRIRDFHHGTGRVLHNHYGPTETHVVTATTLPADPGAWPARPTIGRPIRNTRAYVLDSALRPVQPGVPGELYLAGAGLARGYLGRPDLTAERFTADPYGPAGGRMYRTGDVVRWTGGGELDYLGRSDHQVKIRGFRIELGEIEAALTAHPAVAQAAVLAREDRPGLRTIAAYLVPAAGRTVPTAAELRAHLDGTLPDYMVPSAFVPLAELPLTPNRK", "signature": "DVQYAAHVVK", "extended_signature": "LWHTFDVSAQESYAAQAGEHNHYGPTETHVVTAT", "substrates": [ "proline" ] }, { "name": "XYI78305.1.A2", "sequence": "FERQAARTPEATALVFRDVRLSYAELNTRANRLARRLLADGVRPEQAVAVVLPRSAEQIVALLAVMKAGAVHLPVDAGYPADRVAHMLDDARPVAVLADAAELRAVGSDQAWSGEDLTADERGAAPRPDNAAYVIYTSGSTGRPKGVTVQHRSVANLFHDHFGRLYGPVIAAAGGRRLRASLCASLSFDAAVDPLLWMVAGHELHLLDDETRQDAAALCAYAQRVGGLDYVDTTPGHFQQLHELGLTEGPFRPLIVALGGEAMGETLRADLAAVEGLAAYNLYGPTETTVDALGQRIDDSDRVRVGRPLDNYRAYVLDAALRPVVPGVAGELYLAGAGLARGYLGRPDLTAERFTADPYGAPGARMYRTGDLARWTRDGRIDCLGRVDDQVKVRGFRVELGEIEAALESHEDISQAAVLVREDRPGVRELVAYAVPAAGRPVPAPDELRRRLGDGLPDYMVPAAYVTLDRLPVTVNGK", "signature": "DADDAGLVDK", "extended_signature": "LDHAFDAAVDPWDTALGGEYNLYGPTETTVDALG", "substrates": [ "arginine" ] }, { "name": "XYI78305.1.A3", "sequence": "FEAAVDAGPDAPAVVGGGFELSYAQVEARANRLAHWLIGRGVGVEDVVALVLPRSVDIVVAELAVLKAGAAYLPVDPEYPDERIAFMLEDARPVLVLRELPELGEGLAESRPGVAVSPRSAAYVIYTSGSTGRPKGVVVSHAGLASLAADERFAVDSQSRVLQFASPSFDASVFELTMAFAAGATLVVPPPGPLAGEPLAVLLAEQGVTHATLPPVVLAAMGDAGLPAGMSLVTAGEACSAELVERWSAGRRMVNAYGPTESTVCATMSGPLRAGTGAPSIGRPITNTRVYVLDAALRPVVPGVAGELYLAGAGLARGYLGRPGLTAERFTADPFGAPGARMYRTGDLARWSADGELDYLGRADDQVKVRGFRIELGEIESVVSRFDNAAQAVVVVREDQPGIKRLVAYVVPREGALDVAAIRAHVAATLPDYMVPSAFAELGELPVTVNGK", "signature": "DAFTVAAVCK", "extended_signature": "LDEAFDASVFEMTLVTAGEVNAYGPTESTVCATM", "substrates": [ "phenylalanine" ] } ] }